Heat acclimation

Across TCGA patient cohorts, RNA activity of the Heat acclimation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLOD2, P4HA2, and P4HA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heat acclimation activity versus PLOD2 in LUAD (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLOD2 →	+0.820	+0.068	<.001	<.001	3	8
GBM	P4HA2 →	+0.566	+0.095	<.001	<.001	3	7
GBM	P4HA1 →	+0.478	+0.073	<.001	<.001	3	6
GBM	PLIN2 →	+0.950	+0.093	.001	<.001	3	6
GBM	MMP8 →	+1.493	+0.077	<.001	.001	3	6
PDAC	RNF220_S390 →	-0.374	-0.066	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010286 vs PLOD2 — LUAD

Explore this scatter interactively →