Heat acclimation

Across TCGA patient cohorts, RNA activity of the Heat acclimation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP7, PECAM1, and ABCA6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heat acclimation activity versus GIMAP7 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GIMAP7 →	-0.606	-0.157	.009	<.001	3	4
LSCC	PECAM1 →	-0.422	-0.092	.003	.003	3	4
LUAD	ABCA6 →	-0.463	-0.058	<.001	.002	3	4
GBM	EDNRB →	-0.749	-0.070	.008	.003	2	4
OV	ARNTL →	-0.544	-0.101	.008	.006	3	3
OV	SIGLEC17P →	-0.629	-0.119	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010286 vs GIMAP7 — LSCC

Explore this scatter interactively →