Detoxification of copper ion

Across TCGA patient cohorts, RNA activity of the Detoxification of copper ion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MT1F, MT1E, and VEZF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of copper ion activity versus MT1F in OV (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MT1F →	+1.163	+0.125	<.001	<.001	3	7
LSCC	MT1E →	+1.283	+0.088	<.001	<.001	3	7
OV	VEZF1 →	-0.468	-0.109	<.001	.002	2	7
GBM	CTCF →	-0.449	-0.085	<.001	.001	3	6
CCRCC	SUPT6H →	-0.101	-0.115	.001	<.001	3	6
COAD	WDR5 →	-0.214	-0.082	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010273 vs MT1F — OV

Explore this scatter interactively →