Detoxification of copper ion

Across TCGA pan-cancer cohorts, RNA activity of the Detoxification of copper ion pathway differs between tumor and matched normal tissue in 17 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and KIRP, show the opposite pattern, with lower activity in tumor tissue.

KIRC, KIRP, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Female	IV	−0.189	<.001	12	view →
KIRP	Female	II,III,IV	−0.291	<.001	11	view →
COAD	All	IV	−0.218	<.001	11	view →
THCA	All	IV	−0.214	<.001	11	view →
KICH	Female	II,III,IV	−0.228	<.001	10	view →
LIHC	Female	II,III,IV	−0.310	<.001	9	view →
BRCA	All	All	−0.101	<.001	6	view →
LUSC	Male	II,III,IV	−0.101	<.001	6	view →
CHOL	All	All	−0.296	<.001	5	view →
READ	All	All	−0.240	<.001	5	view →
LUAD	All	All	−0.047	.002	4	view →
HNSC	Male	All	−0.044	.008	4	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 17 lineages.

GO:0010273–KIRC

Open the KIRC breakdown →