Detoxification of copper ion

Across TCGA patient cohorts, RNA activity of the Detoxification of copper ion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1G, MT2A, and MT1F, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of copper ion activity versus MT1G in UCEC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MT1G →	+1.755	+0.669	<.001	<.001	3	5
UCEC	MT2A →	+1.428	+1.047	<.001	<.001	3	5
OV	MT1F →	+1.183	+0.730	<.001	<.001	3	5
UCEC	MT1X →	+0.883	+0.652	<.001	<.001	3	4
LSCC	EEF1A1 →	-0.279	-0.467	.004	.007	3	4
LSCC	RPS27 →	-0.325	-0.474	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010273 vs MT1G — UCEC

Explore this scatter interactively →