Detoxification of copper ion

Across TCGA cell cohorts, RNA activity of the Detoxification of copper ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBG2, TIMM9, and RNF141, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of copper ion activity versus TUBG2 in BLOOD_Leukemia (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TUBG2 →	+2.897	+0.308	<.001	.002	3	2
LUNG_SCLC	TIMM9 →	+0.924	+0.273	.004	.001	3	2
LUNG_SCLC	RNF141 →	+1.240	+0.291	.001	<.001	3	2
LUNG_SCLC	PTBP3 →	+1.437	+0.244	<.001	.004	3	2
LUNG_SCLC	DENND2D →	+3.622	+0.269	<.001	<.001	3	2
LUNG_SCLC	KBTBD3 →	+0.825	+0.222	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010273 vs TUBG2 — BLOOD_Leukemia

Explore this scatter interactively →