Establishment or maintenance of transmembrane electrochemical gradient

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of transmembrane electrochemical gradient pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CROCC, LMNB2, and PARP14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of transmembrane electrochemical gradient activity versus CROCC in CCRCC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CROCC →	-0.278	-0.082	<.001	<.001	3	7
OV	LMNB2 →	-0.406	-0.072	.002	<.001	3	7
PDAC	PARP14 →	+0.297	+0.104	<.001	<.001	3	7
PDAC	PTMS →	-0.380	-0.102	<.001	<.001	3	7
COAD	GPALPP1 →	-0.470	-0.068	<.001	<.001	3	7
COAD	LTBP4 →	-0.453	-0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010248 vs CROCC — CCRCC

Explore this scatter interactively →