Establishment or maintenance of transmembrane electrochemical gradient

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of transmembrane electrochemical gradient pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF506, SERINC2, and SMIM12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF506 grouped by Establishment or maintenance of transmembrane electrochemical gradient-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF506 →	-2.233	-1.359	<.001	.001	3	5
BLOOD_Myeloma	SERINC2 →	-1.387	-1.099	.009	.008	3	4
BONE	SMIM12 →	-0.407	-1.797	.006	<.001	3	4
OVARY	VIL1 →	+0.510	+1.054	.005	.007	2	4
OESOPHAGUS	H2BC12 →	-1.400	-0.900	.001	.002	3	3
LIVER	GNAZ →	+1.783	+1.365	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF506 by Establishment or maintenance of transmembrane electrochemical gradient activity — STOMACH

Explore this box plot interactively →