Establishment or maintenance of transmembrane electrochemical gradient

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of transmembrane electrochemical gradient pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK1N, ATP1B1, and SAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of transmembrane electrochemical gradient activity versus PCSK1N in STOMACH (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PCSK1N →	-3.201	-0.234	<.001	.002	3	5
LUNG_SCLC	ATP1B1 →	+1.818	+0.414	.001	<.001	3	5
LUNG_NSCLC_LUAD	SAT1 →	+1.142	+0.235	.006	<.001	3	5
LARGE_INTESTINE	MAP6D1 →	-1.221	-0.328	<.001	.003	3	4
OESOPHAGUS	SS18L1 →	-1.192	-0.322	<.001	.002	3	4
STOMACH	SOX9 →	+3.156	+0.356	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010248 vs PCSK1N — STOMACH

Explore this scatter interactively →