Vascular transport

Across TCGA cell cohorts, RNA activity of the Vascular transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, CFAP54, and NAA20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular transport activity versus SLC7A5 in LUNG_NSCLC_LUAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC7A5 →	+2.499	+0.282	<.001	<.001	3	7
LIVER	CFAP54 →	+0.562	+0.247	.001	.004	3	4
KIDNEY	NAA20 →	+0.698	+0.350	.007	.006	3	4
LUNG_SCLC	MAGEE1 →	-1.515	-0.323	.002	<.001	3	4
OVARY	TMEM147 →	-0.858	-0.194	<.001	.003	3	4
LUNG_NSCLC_LUAD	FZD5 →	-0.647	-0.155	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010232 vs SLC7A5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →