Response to lithium ion

Across TCGA cell cohorts, RNA activity of the Response to lithium ion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH1, SMOX, and BAG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPH1 grouped by Response to lithium ion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	JPH1 →	-1.251	-1.122	<.001	.004	3	4
LUNG_SCLC	SMOX →	+2.278	+1.190	.002	.007	3	4
SKIN	BAG5 →	+0.525	+0.687	<.001	.006	3	4
STOMACH	SDR42E1 →	+2.203	+1.247	.002	.006	3	3
STOMACH	NDUFS5 →	-0.711	-1.167	.006	.005	3	3
LIVER	CTC1 →	+0.891	+0.974	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPH1 by Response to lithium ion activity — LIVER

Explore this box plot interactively →