Response to UV-B

Across TCGA cell cohorts, RNA activity of the Response to UV-B pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDB2, CDKN1A, and NAT8L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDB2 grouped by Response to UV-B-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DDB2 →	-1.768	-1.397	<.001	<.001	3	5
SKIN	CDKN1A →	-2.839	-1.398	<.001	<.001	3	5
SOFT_TISSUE	NAT8L →	-1.568	-1.746	.002	<.001	3	5
SOFT_TISSUE	CEP41 →	+1.722	+1.342	.007	.008	3	4
UPPER_AERODIGESTIVE_TRACT	NACC2 →	-1.276	-0.322	.006	.001	3	4
SOFT_TISSUE	LYRM9 →	-1.984	-1.820	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDB2 by Response to UV-B activity — SOFT_TISSUE

Explore this box plot interactively →