Response to X-ray

Across TCGA patient cohorts, RNA activity of the Response to X-ray pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCI, RFC5, and GINS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to X-ray activity versus FANCI in BRCA (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FANCI →	+0.464	+0.188	.007	.002	3	6
PDAC	RFC5 →	+0.237	+0.129	.001	<.001	3	6
BRCA	GINS1 →	+0.570	+0.206	.001	<.001	3	5
BRCA	CCNB1 →	+0.733	+0.291	.002	<.001	3	5
BRCA	KIF11 →	+0.634	+0.229	<.001	<.001	3	5
PDAC	KIF20B →	+0.572	+0.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010165 vs FANCI — BRCA

Explore this scatter interactively →