Response to zinc ion

Across TCGA cell cohorts, RNA activity of the Response to zinc ion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA5, ZNF512B, and OSM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KPNA5 grouped by Response to zinc ion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KPNA5 →	-0.489	-0.844	.002	.004	3	4
SKIN	ZNF512B →	+0.547	+1.162	.004	<.001	3	3
SKIN	OSM →	+0.063	+0.824	.008	.003	3	3
BREAST	KDM4C →	-0.534	-0.646	.003	.005	3	3
STOMACH	PGK1 →	+1.058	+1.539	<.001	<.001	3	3
OESOPHAGUS	PMPCA →	-1.061	-1.522	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KPNA5 by Response to zinc ion activity — CNS

Explore this box plot interactively →