Response to zinc ion

Across TCGA cell cohorts, RNA activity of the Response to zinc ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIPC1, BTD, and PFDN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to zinc ion activity versus GIPC1 in BLOOD_Lymphoma (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GIPC1 →	-1.505	-0.313	.009	<.001	3	5
BONE	BTD →	-1.468	-0.368	.001	<.001	3	5
LIVER	PFDN5 →	+0.577	+0.359	.002	.006	2	5
URINARY_TRACT	COL17A1 →	-5.680	-0.453	.001	.002	3	4
OESOPHAGUS	KIAA1671 →	+1.344	+0.430	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP5MC2 →	+0.631	+0.332	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010043 vs GIPC1 — BLOOD_Lymphoma

Explore this scatter interactively →