Response to manganese ion

Across TCGA patient cohorts, RNA activity of the Response to manganese ion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL6A3, CLEC3B, and MMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to manganese ion activity versus COL6A3 in GBM (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A3 →	+0.705	+0.044	.006	.001	3	8
BRCA	CLEC3B →	+0.443	+0.031	<.001	<.001	3	7
UCEC	MMP2 →	+0.769	+0.072	<.001	<.001	3	7
GBM	SERPINA4 →	+0.420	+0.049	.005	<.001	3	7
BRCA	C1S →	+0.537	+0.044	<.001	<.001	3	7
BRCA	COL3A1 →	+0.614	+0.035	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010042 vs COL6A3 — GBM

Explore this scatter interactively →