Response to iron ion

Across TCGA cell cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are B2M, HLA-B, and HLA-G, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron ion activity versus B2M in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	B2M →	+2.667	+0.546	<.001	.004	3	14
BLOOD_Lymphoma	HLA-B →	+2.369	+0.389	<.001	<.001	3	10
OVARY	HLA-G →	+3.288	+0.361	<.001	<.001	3	10
LUNG_SCLC	STMN1 →	-1.699	-0.734	<.001	<.001	3	8
LARGE_INTESTINE	HMGB2 →	-1.570	-0.345	.003	<.001	3	8
KIDNEY	PCNA →	-1.218	-0.351	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010039 vs B2M — LARGE_INTESTINE

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