Cardioblast differentiation

Across TCGA patient cohorts, RNA activity of the Cardioblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3PXD2A_T256, INHBA, and MMP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardioblast differentiation activity versus SH3PXD2A_T256 in BRCA (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH3PXD2A_T256 →	+0.541	+0.034	<.001	<.001	3	6
LSCC	INHBA →	+0.571	+0.052	<.001	<.001	3	6
LSCC	MMP14 →	+0.509	+0.082	<.001	<.001	3	6
LSCC	ASAP1 →	+0.228	+0.066	<.001	<.001	3	5
BRCA	SEC23B →	-0.357	-0.045	<.001	<.001	3	5
BRCA	SERPINH1 →	+0.467	+0.054	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010002 vs SH3PXD2A_T256 — BRCA

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