Oocyte differentiation

Across TCGA cell cohorts, RNA activity of the Oocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSF2, BUD13, and ALKBH8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte differentiation activity versus HSF2 in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HSF2 →	+0.800	+0.888	<.001	.001	3	4
BLOOD_Leukemia	BUD13 →	+0.667	+0.885	.001	.003	3	4
BLOOD_Leukemia	ALKBH8 →	+0.512	+0.715	.004	.007	3	4
BLOOD_Leukemia	CEP57 →	+0.972	+0.976	<.001	.001	3	4
BREAST	ALDH1B1 →	+1.149	+1.008	<.001	<.001	2	5
SKIN	TRIM63 →	-2.372	-0.834	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009994 vs HSF2 — BLOOD_Leukemia

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