Dorsal/ventral pattern formation

Across TCGA patient cohorts, RNA activity of the Dorsal/ventral pattern formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPRC, STAT1, and FARP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal/ventral pattern formation activity versus PTPRC in GBM (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPRC →	-0.542	-0.049	.002	<.001	3	9
LSCC	STAT1 →	-0.539	-0.028	<.001	.002	3	8
GBM	FARP1 →	+0.328	+0.034	<.001	<.001	3	8
COAD	CYBB →	-0.634	-0.020	<.001	.001	3	8
GBM	HCK →	-0.559	-0.047	.001	<.001	3	8
BRCA	GBP5 →	-1.030	-0.035	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009953 vs PTPRC — GBM

Explore this scatter interactively →