Dorsal/ventral pattern formation

Across TCGA patient cohorts, RNA activity of the Dorsal/ventral pattern formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIXDC1, MSRB3, and BNC2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal/ventral pattern formation activity versus DIXDC1 in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIXDC1 →	+0.574	+0.646	.006	<.001	3	4
BRCA	MSRB3 →	+0.927	+0.710	.004	.001	3	4
PDAC	BNC2-AS1 →	+0.663	+0.715	<.001	<.001	3	4
BRCA	ZNF197 →	+0.521	+0.671	.001	.001	3	4
PDAC	FAM32A →	+0.217	+0.579	.001	<.001	3	4
BRCA	P3H3 →	+1.097	+0.665	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009953 vs DIXDC1 — BRCA

Explore this scatter interactively →