Dorsal/ventral pattern formation

Across TCGA cell cohorts, RNA activity of the Dorsal/ventral pattern formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TERF2, EDRF1, and FAM53B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TERF2 grouped by Dorsal/ventral pattern formation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TERF2 →	+0.643	+0.977	<.001	.009	3	4
LUNG_SCLC	EDRF1 →	+0.660	+0.749	.006	.003	3	3
LUNG_NSCLC_LUSC	FAM53B →	+0.730	+1.250	.004	.003	3	3
OVARY	ACADSB →	+1.057	+0.678	<.001	.005	3	3
BLOOD_Lymphoma	NENF →	-1.502	-1.804	.002	<.001	3	3
SKIN	SIX6 →	-0.114	-0.864	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TERF2 by Dorsal/ventral pattern formation activity — LIVER

Explore this box plot interactively →