Anterior/posterior pattern specification

Across TCGA patient cohorts, RNA activity of the Anterior/posterior pattern specification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF213, STK10, and BIN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior pattern specification activity versus RNF213 in LUAD (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNF213 →	-0.406	-0.038	<.001	<.001	3	8
GBM	STK10 →	-0.453	-0.040	<.001	<.001	3	8
UCEC	BIN2 →	-0.431	-0.036	<.001	<.001	3	8
UCEC	CARD9_S460 →	-0.874	-0.062	<.001	<.001	3	8
UCEC	DEF6 →	-0.280	-0.036	<.001	<.001	3	8
UCEC	FYB1 →	-0.452	-0.039	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009952 vs RNF213 — LUAD

Explore this scatter interactively →