Anterior/posterior pattern specification

Across TCGA cell cohorts, RNA activity of the Anterior/posterior pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, FRAT1, and MAGI1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior pattern specification activity versus BASP1 in LIVER (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	BASP1 →	+5.720	+2.173	<.001	<.001	3	10
BREAST	FRAT1 →	-0.906	-1.187	<.001	<.001	3	6
KIDNEY	MAGI1 →	-1.359	-1.201	.006	.001	3	5
SOFT_TISSUE	TMEM14C →	+0.912	+1.392	.001	.001	3	5
SOFT_TISSUE	QSOX1 →	+1.552	+1.598	.008	.002	2	6
BLOOD_Leukemia	SRGN →	+3.047	+0.681	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009952 vs BASP1 — LIVER

Explore this scatter interactively →