Anterior/posterior axis specification

Across TCGA patient cohorts, RNA activity of the Anterior/posterior axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1, BIN2, and EVI2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior axis specification activity versus SIPA1 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SIPA1 →	-0.248	-0.025	.003	.002	3	6
LSCC	BIN2 →	-0.585	-0.061	<.001	<.001	3	6
BRCA	EVI2B →	-0.539	-0.032	<.001	<.001	3	6
LSCC	SAMHD1 →	-0.292	-0.042	<.001	<.001	3	6
HNSC	STK10 →	-0.371	-0.052	<.001	.008	3	6
OV	TBX3_S456 →	+0.812	+0.043	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009948 vs SIPA1 — COAD

Explore this scatter interactively →