Anterior/posterior axis specification

Across TCGA pan-cancer cohorts, RNA activity of the Anterior/posterior axis specification pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 59 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Anterior/posterior axis specification pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, CESC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.494	0.926	.005	52	view →
CESC	OS	Quartile	III,IV	0.227	0.752	.008	30	view →
BRCA	DFS	Median	All	0.967	0.935	.003	28	view →
KIRC	DFS	Tertile	III,IV	0.501	0.671	.017	18	view →
UVM	DFS	Quartile	All	0.340	0.661	.013	12	view →
HNSC	OS	Median	IV	0.477	0.336	.008	11	view →
UCEC	OS	Median	II,III,IV	0.845	0.715	.015	10	view →
ACC	DFS	Quartile	All	0.285	0.748	.007	9	view →
SARC	OS	Quartile	All	0.625	0.826	.026	7	view →
KICH	OS	Tertile	III,IV	0.098	0.735	.014	6	view →
CHOL	OS	Tertile	II,III,IV	0.322	0.961	.031	6	view →
GBM	DFS	Median	All	0.245	0.168	.030	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0009948–KIRP (OS)

Open the KIRP breakdown →