Anterior/posterior axis specification

Across TCGA patient cohorts, RNA activity of the Anterior/posterior axis specification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR497HG, GTF3C4, and CAND1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior axis specification activity versus MIR497HG in UCEC (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR497HG →	+0.395	+0.571	.001	<.001	3	4
BRCA	GTF3C4 →	+0.302	+0.382	.003	.008	3	4
LSCC	CAND1 →	+0.367	+0.399	<.001	.005	3	4
LSCC	LEMD3 →	+0.265	+0.435	.007	.002	3	4
BRCA	RBM12 →	+0.374	+0.540	<.001	.004	3	4
HNSC	UBA5 →	+0.423	+0.505	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009948 vs MIR497HG — UCEC

Explore this scatter interactively →