Anterior/posterior axis specification

Across TCGA cell cohorts, RNA activity of the Anterior/posterior axis specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF425, PDK3, and NRDC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF425 grouped by Anterior/posterior axis specification-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF425 →	+0.754	+1.224	.001	<.001	3	4
LIVER	PDK3 →	+1.323	+1.387	.002	<.001	3	4
LARGE_INTESTINE	NRDC →	+0.452	+0.871	.009	.001	2	5
UPPER_AERODIGESTIVE_TRACT	LCK →	-1.230	-1.050	.001	.004	3	4
OESOPHAGUS	TAGLN2 →	-1.065	-0.743	.002	.001	3	4
URINARY_TRACT	ERVMER34-1 →	-2.140	-1.304	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF425 by Anterior/posterior axis specification activity — LUNG_SCLC

Explore this box plot interactively →