Anterior/posterior axis specification

Across TCGA cell cohorts, RNA activity of the Anterior/posterior axis specification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, SYNPO, and C11orf68, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior axis specification activity versus BASP1 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BASP1 →	+4.821	+1.503	<.001	<.001	3	9
BREAST	SYNPO →	+1.831	+0.995	<.001	.002	3	6
BREAST	C11orf68 →	+1.108	+1.340	<.001	<.001	3	5
LIVER	HRH1 →	+2.421	+1.852	.001	<.001	3	5
LIVER	ITGA3 →	+4.514	+1.434	.001	.001	3	5
LIVER	ADTRP →	+1.256	+1.494	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009948 vs BASP1 — BLOOD_Lymphoma

Explore this scatter interactively →