Epidermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Epidermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO2, ADGRE2, and MEGF10, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epidermal cell differentiation activity versus FBXO2 in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FBXO2 →	+1.051	+0.486	.009	.009	3	1
COAD	ADGRE2 →	-0.672	-0.615	.001	.001	3	1
COAD	MEGF10 →	-0.139	-0.460	.007	.006	3	1
COAD	JOSD2 →	+0.569	+0.675	.001	.004	3	1
COAD	SPATC1 →	-0.198	-0.452	.007	.007	3	1
COAD	MIR580 →	-0.634	-0.593	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009913 vs FBXO2 — COAD

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