Specification of symmetry

Across TCGA patient cohorts, RNA activity of the Specification of symmetry pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MIOS_S766, CNPY4, and STAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Specification of symmetry activity versus MIOS_S766 in BRCA (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIOS_S766 →	-0.419	-0.023	<.001	<.001	3	9
UCEC	CNPY4 →	+0.362	+0.050	.001	.005	3	8
CCRCC	STAT1 →	-0.505	-0.022	<.001	<.001	3	8
HNSC	STAT1_S532 →	-0.830	-0.032	<.001	.001	3	8
BRCA	BDH2 →	+0.431	+0.022	<.001	<.001	3	8
BRCA	RPL12_S38 →	-1.085	-0.034	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009799 vs MIOS_S766 — BRCA

Explore this scatter interactively →