Specification of symmetry

Across TCGA patient cohorts, RNA activity of the Specification of symmetry pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUCY1A2, ZCCHC24, and ADAMTS10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Specification of symmetry activity versus GUCY1A2 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GUCY1A2 →	+0.723	+0.389	<.001	<.001	3	6
BRCA	ZCCHC24 →	+0.854	+0.530	<.001	<.001	3	6
LSCC	ADAMTS10 →	+0.405	+0.252	.002	.009	3	5
BRCA	CKS1B →	-0.533	-0.310	.001	.009	3	5
BRCA	LAMA2 →	+0.805	+0.360	<.001	.002	3	5
HNSC	ENOX1 →	+0.717	+0.257	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009799 vs GUCY1A2 — LSCC

Explore this scatter interactively →