Specification of symmetry

Across TCGA cell cohorts, RNA activity of the Specification of symmetry pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAXE, RNF126, and KRT8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Specification of symmetry activity versus NAXE in PANCREAS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NAXE →	-0.857	-0.871	.004	.003	3	5
LUNG_NSCLC_LUAD	RNF126 →	-0.448	-0.510	<.001	.001	3	5
SOFT_TISSUE	KRT8 →	+5.346	+1.026	<.001	.004	3	5
STOMACH	SPC24 →	-1.498	-1.349	.004	<.001	3	5
PANCREAS	THOP1 →	-0.972	-0.900	<.001	.002	3	5
SOFT_TISSUE	AOX1 →	+3.744	+1.316	.008	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009799 vs NAXE — PANCREAS

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