Post-embryonic development

Across TCGA patient cohorts, RNA activity of the Post-embryonic development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STIP1_S481, VIM_S72, and KANK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-embryonic development activity versus STIP1_S481 in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STIP1_S481 →	-0.711	-0.046	<.001	<.001	3	8
OV	VIM_S72 →	+1.475	+0.041	.005	.007	3	8
OV	KANK2 →	+0.473	+0.050	<.001	<.001	3	7
OV	LRP1 →	+0.477	+0.046	<.001	<.001	3	7
UCEC	MYLK →	+1.027	+0.071	<.001	<.001	3	7
UCEC	PRELP →	+1.013	+0.069	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009791 vs STIP1_S481 — LSCC

Explore this scatter interactively →