Response to carbohydrate

Across TCGA patient cohorts, RNA activity of the Response to carbohydrate pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, SRRM2, and SULF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to carbohydrate activity versus SERBP1 in BRCA (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERBP1 →	-0.162	-0.011	.002	.003	3	6
GBM	SRRM2 →	-0.245	-0.033	<.001	<.001	3	6
COAD	SULF1 →	+0.483	+0.018	.004	.001	3	6
BRCA	CNN2 →	+0.549	+0.018	.001	.002	3	6
BRCA	SEPTIN8 →	+0.255	+0.012	<.001	.002	3	6
BRCA	NIFK →	-0.476	-0.017	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009743 vs SERBP1 — BRCA

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