Response to blue light

Across TCGA patient cohorts, RNA activity of the Response to blue light pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIK3C2A_S259, SMG9_S32, and NCK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to blue light activity versus PIK3C2A_S259 in PDAC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PIK3C2A_S259 →	+0.462	+0.062	.001	.004	3	5
BRCA	SMG9_S32 →	+0.266	+0.043	.008	.003	3	5
BRCA	NCK1 →	-0.252	-0.053	<.001	.004	3	5
GBM	NFATC2_S236 →	-0.449	-0.099	.004	.001	2	6
GBM	LCP2 →	-0.310	-0.078	.001	<.001	3	5
GBM	KIF21A_S1212 →	+0.404	+0.071	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009637 vs PIK3C2A_S259 — PDAC

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