Response to blue light

Across TCGA patient cohorts, RNA activity of the Response to blue light pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASCC3, LZTS2, and EIF3FP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to blue light activity versus ASCC3 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ASCC3 →	+0.626	+0.133	<.001	.001	3	3
GBM	LZTS2 →	-0.578	-0.176	<.001	.009	3	2
LSCC	EIF3FP3 →	-0.493	-0.160	.002	.005	3	2
BRCA	SERINC1 →	+0.887	+0.089	.003	.001	3	2
HNSC	SOX12 →	-0.807	-0.120	.005	.004	3	2
HNSC	MLLT11 →	-2.042	-0.123	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009637 vs ASCC3 — HNSC

Explore this scatter interactively →