Response to blue light

Across TCGA cell cohorts, RNA activity of the Response to blue light pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B1, ANAPC1, and FBXO22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2B1 grouped by Response to blue light-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF2B1 →	+0.377	+0.783	.003	.006	3	4
BLOOD_Leukemia	ANAPC1 →	+0.731	+1.211	.008	<.001	3	4
BLOOD_Leukemia	FBXO22 →	+0.730	+0.883	<.001	.001	3	4
BLOOD_Leukemia	AAAS →	+0.431	+0.861	<.001	.002	3	4
SOFT_TISSUE	UBE4A →	+0.577	+1.024	.001	.003	3	4
SOFT_TISSUE	TRIP12 →	+0.745	+1.244	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2B1 by Response to blue light activity — BLOOD_Leukemia

Explore this box plot interactively →