Response to blue light

Across TCGA cell cohorts, RNA activity of the Response to blue light pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH16A1, ZNF248, and CRTC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH16A1 grouped by Response to blue light-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ALDH16A1 →	-0.210	-0.070	.008	.008	3	4
KIDNEY	ZNF248 →	-0.208	-0.096	.002	.005	3	4
BONE	CRTC1 →	+0.220	+0.240	.004	.006	3	3
STOMACH	KIRREL1 →	+0.178	+0.123	.004	.003	2	4
BLOOD_Myeloma	EMP1 →	+0.313	+0.141	.003	.003	3	3
LARGE_INTESTINE	S100A8 →	-0.203	-0.101	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH16A1 by Response to blue light activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →