Response to gravity

Across TCGA patient cohorts, RNA activity of the Response to gravity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN6, TNFAIP8, and UNC13D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gravity activity versus PTPN6 in GBM (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN6 →	+0.709	+0.145	<.001	<.001	3	8
GBM	TNFAIP8 →	+0.779	+0.134	<.001	<.001	3	8
GBM	UNC13D →	+0.454	+0.095	<.001	<.001	3	8
GBM	CASP4 →	+0.617	+0.126	<.001	<.001	3	8
GBM	DEF6 →	+0.588	+0.141	<.001	<.001	3	8
GBM	HNRNPU →	-0.341	-0.148	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009629 vs PTPN6 — GBM

Explore this scatter interactively →