Response to gravity

Across TCGA patient cohorts, RNA activity of the Response to gravity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVI2B_S268, PTAFR_S339, and CBL_S804, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gravity activity versus EVI2B_S268 in COAD (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EVI2B_S268 →	+1.046	+0.419	.005	.008	2	5
CCRCC	PTAFR_S339 →	+1.185	+0.392	<.001	<.001	3	4
BRCA	CBL_S804 →	+0.765	+0.311	<.001	<.001	3	3
BRCA	FGD2_S654 →	+0.436	+0.241	<.001	<.001	3	3
BRCA	RASAL3_S857 →	+0.805	+0.409	<.001	<.001	3	3
HNSC	SUGP2 →	-0.380	-0.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009629 vs EVI2B_S268 — COAD

Explore this scatter interactively →