Response to gravity

Across TCGA cell cohorts, RNA activity of the Response to gravity pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOS, MSTN, and BGLAP, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOS grouped by Response to gravity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FOS →	-0.246	-1.339	.007	.003	3	12
BLOOD_Leukemia	MSTN →	-0.257	-1.254	.002	.004	2	9
LARGE_INTESTINE	BGLAP →	-0.180	-1.244	<.001	<.001	3	8
BREAST	SLC17A1 →	-0.325	-0.955	.001	.003	3	6
LUNG_SCLC	NOX3 →	-0.316	-1.841	.002	.004	3	6
OVARY	PMF1 →	+0.204	+1.325	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOS by Response to gravity activity — LIVER

Explore this box plot interactively →