Response to gravity

Across TCGA cell cohorts, RNA activity of the Response to gravity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP8, DNMT3B, and RANBP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CASP8 grouped by Response to gravity-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CASP8 →	-0.265	-0.360	<.001	.001	3	4
SOFT_TISSUE	DNMT3B →	+0.223	+0.252	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	RANBP9 →	+0.211	+0.149	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	PSTPIP1 →	+0.153	+0.161	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PADI3 →	-0.223	-0.165	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLC10A4 →	+0.130	+0.162	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CASP8 by Response to gravity activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →