Response to fungus

Across TCGA patient cohorts, RNA activity of the Response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, S100A8, and LCP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fungus activity versus BCL2A1 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCL2A1 →	+1.397	+0.223	<.001	<.001	3	8
BRCA	S100A8 →	+2.022	+0.209	<.001	<.001	3	7
OV	LCP2 →	+0.889	+0.211	.004	.003	3	7
HNSC	MEFV →	+0.815	+0.272	<.001	<.001	3	7
GBM	FPR2 →	+1.075	+0.223	<.001	<.001	3	7
GBM	LILRB3 →	+0.785	+0.181	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009620 vs BCL2A1 — GBM

Explore this scatter interactively →