Response to fungus

Across TCGA pan-cancer cohorts, RNA activity of the Response to fungus pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 66 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Response to fungus pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and CHOL, show the opposite pattern, with higher activity associated with better survival.

LGG, SKCM, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.627	0.841	<.001	54	view →
SKCM	OS	Median	All	0.457	0.239	<.001	49	view →
CHOL	DFS	Tertile	All	0.794	0.215	.010	31	view →
ESCA	DFS	Tertile	III,IV	0.610	0.262	<.001	30	view →
CESC	DFS	Quartile	All	0.870	0.642	.001	26	view →
UVM	DFS	Median	II,III,IV	0.551	0.878	.001	26	view →
STAD	OS	Tertile	III,IV	0.722	0.482	.008	26	view →
LUAD	DFS	Quartile	All	0.802	0.598	<.001	25	view →
DLBC	DFS	Median	IV	1.000	0.281	.005	19	view →
UCEC	OS	Tertile	IV	0.647	0.244	.024	18	view →
MESO	OS	Median	All	0.603	0.481	.016	17	view →
READ	DFS	Tertile	IV	0.179	0.936	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0009620–LGG (DFS)

Open the LGG breakdown →