Response to fungus

Across TCGA cell cohorts, RNA activity of the Response to fungus pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A9, OR5A1, and HADH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC12A9 grouped by Response to fungus-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC12A9 →	-0.491	-1.523	.003	<.001	3	4
SKIN	OR5A1 →	+0.202	+0.690	.003	.009	3	3
CNS	HADH →	+0.261	+0.989	.008	.006	3	3
CNS	PDILT →	+0.266	+0.904	.005	.006	3	3
BONE	CD1B →	-0.218	-0.212	.009	.007	3	3
LUNG_NSCLC_LUAD	PFKFB3 →	+0.123	+0.962	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC12A9 by Response to fungus activity — SOFT_TISSUE

Explore this box plot interactively →