Response to fungus

Across TCGA cell cohorts, RNA activity of the Response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMS3, ZNF709, and YIPF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fungus activity versus LIMS3 in LARGE_INTESTINE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LIMS3 →	-1.290	-0.186	<.001	<.001	3	4
URINARY_TRACT	ZNF709 →	+0.492	+0.197	.006	.004	3	4
BLOOD_Lymphoma	YIPF4 →	-0.688	-0.166	.003	.003	3	4
BLOOD_Lymphoma	SERINC3 →	-0.832	-0.167	<.001	.002	3	4
CNS	MRPS5 →	+0.477	+0.165	.004	.009	3	4
CNS	PTTG1IP →	-0.697	-0.163	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009620 vs LIMS3 — LARGE_INTESTINE

Explore this scatter interactively →