Response to mechanical stimulus

Across TCGA patient cohorts, RNA activity of the Response to mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, CRISPLD2, and CCN2, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mechanical stimulus activity versus TLR4 in SKCM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TLR4 →	+1.305	+0.019	<.001	<.001	3	31
KICH	CRISPLD2 →	+1.448	+0.014	<.001	<.001	3	30
CHOL	CCN2 →	+2.783	+0.042	<.001	<.001	3	30
MESO	ZFP36 →	+2.341	+0.027	<.001	<.001	3	30
THYM	CTTNBP2NL →	+1.576	+0.041	<.001	<.001	3	30
LGG	MSN →	+1.164	+0.017	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009612 vs TLR4 — SKCM

Explore this scatter interactively →