Response to symbiont

Across TCGA cell cohorts, RNA activity of the Response to symbiont pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD3, CHCHD3, and MAN1C1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLOD3 grouped by Response to symbiont-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLOD3 →	+0.741	+0.304	.008	.001	3	4
OVARY	CHCHD3 →	+0.819	+0.778	<.001	.009	3	3
KIDNEY	MAN1C1 →	-0.286	-0.650	.005	.001	3	3
CNS	HIVEP2 →	+1.172	+0.753	.001	.007	3	3
CNS	BLZF1 →	+0.433	+0.636	.004	.007	3	3
BLOOD_Leukemia	DLX1 →	+2.377	+0.474	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLOD3 by Response to symbiont activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →