Detection of biotic stimulus

Across TCGA patient cohorts, RNA activity of the Detection of biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM8, VDR, and NCF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of biotic stimulus activity versus ADAM8 in GBM (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADAM8 →	+1.343	+0.217	<.001	.001	3	6
GBM	VDR →	+0.875	+0.212	<.001	.001	3	5
GBM	NCF2 →	+1.009	+0.274	<.001	<.001	3	5
PDAC	NRP2 →	+0.752	+0.155	<.001	.001	3	5
GBM	ALOX5AP →	+0.921	+0.250	.004	<.001	3	5
PDAC	PPP1R18 →	+0.540	+0.181	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009595 vs ADAM8 — GBM

Explore this scatter interactively →